Zapping the brain with electrical currents could potentially prevent dementia symptoms up to 20 years before they start, according to a study conducted on mice in Tel Aviv, Israel. Researchers found that by targeting the areas of the brain damaged during Alzheimer's, they were able to stop the decay of brain cells and prevent memory loss and cognitive decline. By delivering low-level electrical waves through surgically attached electrodes, the team was able to prevent the formation of harmful proteins in the brain and stop the brain's memory center from shrinking.

Early Detection and Prevention

The study suggests that this electrical stimulation could potentially predict the onset of Alzheimer's in humans up to 10 to 20 years before diagnosis. Study author Dr. Inna Slutsky stated, "This indicates a potential for predicting the disease in the dormant state, before the onset of cognitive decline." The researchers analyzed changes in the brain that occur during sleep, as early signs of the condition often develop during this time.

Silent Seizures and Brain Deterioration

The researchers found that the mice experienced "silent seizures" in the brain's memory center, known as the hippocampus, while sleeping. These seizures did not cause any outward symptoms but could be signs of brain deterioration. To prevent this excess activity, the team used deep brain stimulation (DBS), a surgical procedure involving the placement of electrodes in specific areas of the brain. These electrodes are connected to a device under the skin, which sends electrical pulses to counteract abnormal brain signals.

Protective Measures Against Cognitive Decline

Patients with Alzheimer's often show signs of brain deterioration, such as the build-up of harmful proteins and shrinkage of the hippocampus. The researchers focused on finding protective measures against this decline. In the study, they found that DBS suppressed excess brain activity and prevented cognitive decline up to 20 years before the onset of Alzheimer's. The team plans to pursue human clinical trials next.

About Alzheimer's Disease

Alzheimer's disease is the most common form of dementia, impacting memory, thinking, and behavior. Common symptoms include memory loss, confusion, difficulty communicating, and mobility issues. According to the Alzheimer's Association, over six million Americans have the condition, with the majority being aged 75 or older.

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